Enzo Cucchi was born in Morro d'Alba, a farm village in the province of Ancona on the Adriatic coast in central Italy. During his childhood, he moved to Ancona, the provincial capital, where he lived with his aunt.

He started drawing in 1970s. In 1977 he presented a one-man show and in the next decade he has been given one-man shows by many of the world's museums, including the Guggenheim museum in New York and the Centre Georges Pompidou in Paris. This year's exhibition (1996) was the first large-scale of his in Japan.

At present Enzo Cucchi lives and works in Ancona and Rome. Both cities are places he has chosen as sources of inspiration and subjects for his work.